Panacea Journal of Medical Sciences

Official Publication of NKP Salve Institute of Medical Sciences and Research Centre


Volume 15, Issue 2, Year 2025, No of articles 48
Editorial
Laboratorians are from Venus, clinicians are from Mars: The imperative of communication in patient-centred diagnostics
Author details: Asitava Deb Roy
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Original Article
An observational study to evaluate Loss To Follow-Up (LTFU) rate and treatment outcomes of pulmonary tuberculosis patients in the Dehradun district
Author details: Shiv Kumar Yadav, Richa Sinha, A R Piyush, Dheeraj Gupta
Introduction: Tuberculosis case detection, treatment adherence, and treatment outcomes have significantly improved over the past decade. However, it is essential to identify the ongoing barriers at both grassroots and programmatic levels to enhance these areas, enabling India to move closer to its g....
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Elevated inflammatory markers in pre-diabetic individuals: correlation with hs-CRP & implications for cardiovascular disease prevention
Author details: Soma Lahiri
Background: Pre-diabetes is a condition characterized by elevated blood glucose levels that fall below the diagnostic thresholds for diabetes. It is a precursor to Type 2 diabetes and is associated with an increased risk of cardiovascular diseases (CVD) due to systemic inflammation. Inflammatory mar....
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Breast hamartoma: A clinicopathological analysis and management of cases in our institute over the past decade
Author details: Samarendra Satpathy, Mukti Prasad Mishra, Rashmita Panigrahi, Rashmi Ranjan Beura, Deeptee Mayee Sahoo
Aims and Objectives: This study shares our journey with breast hamartoma at our institute VIMSAR, BURLA over the past decade (2014-2024).Background: Breast hamartoma, a rare type of breast tumor, makes up about 4.8% of all benign breast masses. People don’t talk about it often. The cause still a bit....
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Meniscus or not: The radio-humeral synovial folds & its clinical importance
Author details: Sarbani Das, Pallab Kumar Saha, Gargi Mukherjee, Swapan Bhattacharjee, Arpita Sen
Introduction: Synovial folds present within the humero-radial compartment of elbow joint are prone to chronic inflammation in repeated users of elbow joint, mainly in athletes. Generally, these conditions are well managed with conservative medications, but if not cured, arthroscopic guided resection....
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Study of adverse drug reactions (ADR’S) requiring change in anti-tubercular regimen in multi-drug resistant tuberculosis (MDR-TB) patients in a tertiary healthcare centre
Author details: Ashwin Unni, Priti Meshram, Vishwanath Pujari, Rohit Hegde
Introduction: Multi Drug Resistant Tuberculosis is fast emerging as a global health problem, especially in developing countries like India with a high Tuberculosis burden and poses a major hurdle in the fight against eliminating Tuberculosis. Considering the long duration of treatment in patients of....
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CK-MB and LDH as predictor of HIE in term babies born with perinatal asphyxia
Author details: Jesmin Hussain, Anupama Deka, Ipsita Mahapatra
Background: One prevalent issue affecting newborns is perinatal asphyxia, which has a substantial impact on the morbidity and mortality of newborns. Perinatal asphyxia can affect all the organ systems with a higher predilection for the nervous system resulting in neurological dysfunction which has b....
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Prevalence of nasal carriage of methicillin resistant Staphylococcus aureus among health care workers in a teaching hospital in Eastern India
Author details: Chandra Samatirtha, Bid Sabyasachi, Karmakar Shreyasi, Das Raktim
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a strain of antibiotic-resistant Staphylococcus aureus that has acquired resistance to beta-lactam antibiotics. The emergence of MRSA has significantly enhanced the morbidity and mortality of infected people. It has threatened healt....
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To evaluate the level of anxiety and depression in patients admitted in surgical wards: A cross-sectional study
Author details: Deherkar Juthikaa, Abhay Kumar, Swapnil Pramod Korde
Introduction: To evaluate anxiety and depression, and their prevalence and risk factors in preoperative patients admitted in general surgery wards. Assessing the need for appropriate interventions to better manage these conditions allowing for better outcomes.Materials and Methods: The study involve....
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Comparison of cisplatin doublet therapy in non-small cell lung cancer
Author details: Mohammed Danish, Huma Firdaus, Nafees Ahmad Khan
Introduction: Patients with lung cancer may be eligible for a variety of therapies, including surgery, radiation, chemotherapy, and targeted therapy, depending on their stage. Specific mutations have been identified thanks to breakthroughs in genetics and biomarker testing, allowing for more persona....
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A morphological and morphometric study on supratrochlear foramen in human humerus with its clinical implication
Author details: Chiranjib Bapuli, Pallab Kumar Saha, Banani Kundu
Background: The supratrochlear foramen (STF) is an aperture present at the bony septum in the lower end of humerus that separates olecranon fossa from coronoid fossa. Although it holds significant clinical importance, it has not been extensively studied.Aim: The present study is carried out to asses....
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Coagulation profile and Platelet indices as a predictive marker in Gestational Hypertension and Pre-eclampsia- A case-control study of 260 cases
Author details: Sweta ,, Mayank Agrawal, Rajeev Sen
Introduction: Pregnancy-induced hypertension (PIH) is the leading medical condition during pregnancy that can result in multiple organ systems failing in the mother. PIH is recognized worldwide as a major cause of illness and death in both mothers and newborns. This research aimed to compare platele....
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Clinical insights of H1N1 and H3N2 influenza viruses: A study from the Kalyana-Karnataka region
Author details: Vaibhav C Padashetti, Abhishek Malipatil, Sai Pavan IN, Chethan Kumar BP, Shashidhar Mugali, Shilpa Malipatil, Prakash Hadimani
Background: Influenza viruses, particularly H1N1 and H3N2 variants, present significant public health challenges worldwide due to their potential to cause severe respiratory illnesses.Aim and Objective: To investigate the clinical characteristics, prevalence, and treatment outcomes of confirmed H1N1....
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Evaluation of Acinetobacter baumannii antibiotic resistance from tertiary care hospital – Judging the silent storm
Author details: Bhabhor Ullas H, Patel Alpa S, Mullan Summaiya A
Introduction: Over the closing decades, Acinetobacter baumannii has globally emerged as an enormously troublesome nosocomial pathogen. Its scientific importance has been in large part pushed through a fantastic cap potential to&nb....
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Bolstering blood safety: Revealing six years of vigilance-NAT testing trends in infectious markers among tertiary care centre blood donors
Author details: Sudha Srinivasan, Samuvelraj S, Kundhavai Chandrasekaran, Femela Muniraj
Background: Transfusion transmitted disease was a major risk factor for Blood Transfusion. TTIs (HBV, HCV, HIV, Syphilis, Malaria) screening by ELISA was done mandatory for screening of Blood donors. In order to provide additional layer of safety IDNAT was implemented nowadays in few blood cent....
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To evaluate the visual outcome after phacoemulsification in diabetic patient and non-diabetic patient
Author details: Pratik Sharma, Devanshi Mahesh Dalal, Mahesh Chandra, Gaurav Dubey, Shamit Pal, Ayush Jha
Background: This study investigates visual outcomes after phacoemulsification in non-diabetic and diabetic patients, highlighting cataract as a complication of diabetes mellitus, which affects 285 million people globally. Cataract is the leading cause of blindness, impacting 18 million people worldw....
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The role of diffusion tensor imaging in the early detection and prognosis of cervical spondylotic myelopathy
Author details: Rahul Solanki, Ugan Singh Meena, Madhur Choudhary, Devendra Kumar Purohit
Background: Cervical spondylotic myelopathy (CSM) is a spinal disorder stemming from cervical spine degeneration, elevating the potential for spinal cord damage. Diffusion tensor imaging (DTI) represents an advanced MRI technique utilized to detect subtle alterations in the spinal cord induced by CS....
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Anterior cervical discectomy & fusion using only cage: An institutional experiences
Author details: Poonia Nemi Chand, Surendra Jain, Hardika Poonia
Background: Anterior Cervical Discectomy and Fusion (ACDF) using a standalone cage represents a pivotal advancement in the surgical management of cervical degenerative disc disease. This study evaluates the efficacy, safety, and clinical outcomes of ACDF performed with a standalone cage without usin....
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Evaluating the impact of a research methodology workshop on medical postgraduates and faculty: A pretest-post-test analysis
Author details: Amrita Sarkar, Noyomi Saring, Ramapati Sanyal, Dusu Lalin
Introduction: Research methodology is pivotal in medical practice, providing a structured framework for investigating health phenomena and advancing medical knowledge. However, many medical practitioners lack participation in research activities, and postgraduate training often lacks comprehensive r....
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Demographic and immunological status of Seronegative HLAB27 patients in Central India -A prospective study
Author details: Sadhna Sodani, Debjani Taraphdar, Ranjana Hawaldar
Introduction: HLA B27 is a class I major histocompatibility antigen, which can cause susceptibility to several diseases, including ankylosing spondylitis, reactive arthritis (Reiter's syndrome), inflammatory bowel disease, and psoriasis.Aim and Objective: The present study aims to analyse the demogr....
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Histopathological study of lung malignancies on small biopsies - A tertiary care experience in Central India
Author details: Ankita Piyush Kolhe, Amrapali Gaikwad, Anjali Bode, Rekha Patil Patil, Balwant Kowe
Introduction: Lung cancer accounts for 5.9% of all cancer cases and 8.1% of cancer-related deaths in India. In patients with advanced lung malignancies, CT‐guided needle biopsy (CTNB) was conducted as they are less invasive and are preferrable to resection to make a pathological diagnosis.Materials....
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Predominant ailments among patients attending ENT OPD in Tertiary care centre
Author details: Stuti Shukla, Rohit Saxena, Amit Kumar Sharma
Background: Otorhinolaryngological diseases are common in the general population and can have a significant impact on an individual's quality of life. The study aimed to determine the prevalence of otorhinolaryngological diseases in patients attending the ENT OPD in a tertiary care center.Materials....
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Outcome of retrograde facial nerve dissection in superficial parotidectomy
Author details: Mukti Prasad Mishra, Samarendra Satpathy, Rashmita Panigrahi, Abhijit Das, Anand Seba Tirkey
Background: Using retrograde dissection for doing parotidectomy is technically easier avoiding injury to the facial nerve trunk or other branches. The goal is to remove just the part of the parotid gland where the tumor is. This method can lead shorter surgery times and less blood loss. Plus, it doe....
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Aerobic microbiological profile and antibiogram in sterile body fluids from a tertiary care centre in Kashmir Valley
Author details: Talat Masoodi, Saika Khursheed, Omar Rashid
Background: Infections involving sterile bodily fluids, particularly those linked to healthcare settings are substantial and major sources of mortality and morbidity. The identification of species-level bacteria and their antimicrobial resistance profile are crucial factors to consider when choosing....
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A study of cognitive function, quality of sleep, and Stroop effect among adolescent girls with premenstrual syndrome
Author details: T Dinesh, M Abarna, JB Ashraf Ali
Background: Premenstrual syndrome (PMS) involves various somatic and psychological symptoms related to the luteal phase of the menstrual cycle, ranging from mild discomfort to disability and impacting daily life.Objective: To compare cognitive function, sleep quality, and the Stroop effect between a....
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Evaluation of mesenteric lymph nodes by ultrasonography and it’s clinical correlation in pediatric patients
Author details: Hari Singh, Kamini Yadav, Nikhil Sharma, Nikhil Sharma, Madhu Nayak, Rajoo Patel
Background: Pain abdomen is common symptom in children, increasing use of abdominal ultrasound in the screening and follow-up of patients with pain abdomen, enlargement of the regional mesenteric lymph nodes have become a fairly common finding, particularly in children and young adults.Aims:  E....
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Clinical characteristics and outcome of patients hospitalised with Scrub typus -A tertiary care hospital study in Northern India
Author details: Rajinder Kumar, Isha Sharma, Muzaffar Majeed Khujwal
Background: Scrub typhus is a re-emerging but under-reported infectious diseases that leads to significant morbidity and mortality, if failed to diagnose at appropriate time. The objective of the present study was to, know the Clinical Characteristics and Outcome of adult patients hospitalised with....
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A study to explore the perception of cadaveric oath taking ceremony in medical students of West Bengal
Author details: Satyajit Saha, Sarmistha Chakraborty, Subhajit Halder, Oyndrila Sengupta, Tapan Kumar Jana, Suchi Agarwal
Background: “Cadaver is our first teacher” is most probably the first line that every medical student hears when they enter the dissection hall for the very first time. Every medical practitioner is indebted to these great souls who donated their body posthumously and to their families. From the yea....
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Lipid accumulation product index and TG/HDL-C as a predictor for insulin resistance in diabetes mellitus - A cross-sectional pilot study
Author details: Palak Hemrajani, Madhur Gupta, Arti Kasulkar, Harsh Salankar, Kedar Deshpande
Background: The prevalence of type 2 diabetes mellitus (T2DM) is mounting over the world and said to be directly proportional to obesity. It is known that Lipid Accumulation Product Index (LAPI) in T2DM is related with insulin resistance and inflammation.Materials and Methods: An analytical cross-se....
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Development and validation of intraoperative severity score during laparoscopic cholecystectomy- An observational study
Author details: Amarendra Kumar Singh, Shantanu Kumar Sahu, Bikram Rout, Pankaj Kumar, Ankit Singh
Background: Various studies have been carried out to evaluate the risk of pre-operative conversion in laparoscopic cholecystectomy. Different pre-operative scoring techniques have been recommended using different criteria which further add to the controversy.Materials and Methods: This prospective o....
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Squash cytology- Useful tool to diagnose fungal infection in COVID patient
Author details: Snehal Fakira Jumnake, Nilima Dilip Lodha, Kiran S Bharati, Aishwarya Bhongade
Objective: This study aims to diagnose fungal infections in post-COVID-19 patients using both squash cytology and histology to minimize morbidity and mortality.Materials and Methods: Conducted at a tertiary medical center over six months, this prospective observational study included hospitalized pa....
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A case control study to assess clinical and lipid profile in patients with xanthelasma palpebrarum in a tertiary care centre
Author details: Mahanthesh P, Sachin Somashekhar, Hrishikesh Shivakumar, Anugraha Durairaj
Background: Xanthelasma palpebrarum is used to describe xanthoma that occurs on the eyelids or inner canthi of the eyes. It is frequently associated with cardiovascular disease, diabetes, obesityetc. Various authors have found a positive relationship between xanthelasma palpebrarum and lipid profile....
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Prevalence of non-alcoholic fatty liver disease and left ventricular diastolic dysfunction in newly diagnosed type II diabetes mellitus: an observational, cross-sectional study
Author details: Sona Kaushal, Neeraj Ganju, Kiran K Mokta, Jatinder K Mokta, Ramesh Gulepa
Introduction: Diabetes mellitus with its micro and macro vascular complication is one of the most researched topic in diabetology, but emergence of non-alcoholic fatty liver disease (NAFLD) and left ventricular diastolic dysfunction (LVDD) as its major complications has been given due consideration....
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Role of ultrasonography in diagnosing early rheumatoid arthritis and it’s remission
Author details: Mohit Gopal Varshney, Hari Singh, Archit Gupta, Amrit Goyal, Nikhil Sharma, Nikhil Sharma, Lipika Gupta
Background: Rheumatoid Arthritis is an autoimmune disorder primarily affecting the synovial tissue. Over the past ten years, advancements in ultrasonography quality have made it possible to employ higher ultrasonic frequencies, leading to an improvement in the quality of ultrasound examinations of s....
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Expression of telocytes in cardiovascular diseases
Author details: Aradhana Harrison, Jyothi Ananthraj, Karishma K, A M Vejay Viknesh, C Jahnavi, Rajshree Choudhary, Aswathy Prabha
Background: Telocytes are recently discovered cells that reprogram the terminally differentiated cardiomyocytes to re-enter the cell cycle. Their activity is also altered in atherosclerotic blood vessels. Telocytes express CD117/c-kit. This study focuses on the significance of changes in the express....
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An assessment of knowledge, attitudes, and practices on hand hygiene among medical students with in a healthcare facility
Author details: Divya Sharma, Disha Sharma
Background: Hospital-acquired infections (HAIs) are a significant concern globally. Horizontal transmission, where pathogens spread from one patient to another or from healthcare workers to patients, is a common route of transmission for hospital-acquired microbes. Factors such as inadequate hand hy....
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Assessment of the epidemiological overlap among morphologically identical species of entamoeba among the patients attending Calcutta school of tropical medicine
Author details: Soumya Biswas, Shantanu Mandal, Arani Debnandi, Abhishek Sengupta, Tapashi Ghosh
Introduction: Parasitic infections like Amoebiasis are endemic to most tropical and subtropical regions of developing countries like India. Among Entamoeba species, Entamoeba histolytica, the causative agent for amoebiasis, is highly pathogenic while the other species are considered as non-pathogeni....
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Neutrophil-to-lymphocyte ratio (NLR) in the acute coronary syndrome patients presenting in the pre and post-COVID-19 era
Author details: Vikas Chaudhary, Ashwani Kumar, Kuldeep S Laller, Amit Kumar
Background: The inflammatory pathways play a key role in the pathogenesis of acute coronary syndrome and the severe forms of COVID-19 disease. Thus inflammation may play an interrelation between these two critical situations.Materials and Methods: In this study, the records of the patients of A....
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Assessment of microalbuminuria and urinary albumin-to-creatinine ratio in patients with type 2 diabetes mellitus at a tertiary care hospital
Author details: Alak Kumar Das, Poulami Paul, Jinia Ghosh
Introduction: Urinary albumin-to-creatinine ratio (UACR) in random samples has been considered as the most appropriate investigation to detect early renal impairment. Present study was conducted to assess the microalbuminuria (MA) and UACR in patients with type 2 diabetes mellitus (T2DM) and to eval....
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Acute kidney injury in hospitalized children with dengue infection: A tertiary care hospital study
Author details: Abhishek Chambial, Koushal Kumar Khajuria, Ghanshyam Saini
Background: Dengue viral infection (DVI) is a prevalent arthropod-borne illness, particularly common in tropical regions, manifesting in various clinical presentations ranging from undifferentiated fever to severe hemorrhagic fever and shock. Despite its recognition, acute kidney injury (AKI) remain....
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A rare convergence: Unveiling the uncommon presentation of trichoblastic carcinoma with cylindroma – A singular case report
Author details: Pratiksha Mishra, Meenakshi Mohapatro, Chinmayee Lenka, Fakir Charan Munda, Suryakanti Prusty, Lity Mohanty
Trichoblastic carcinoma is an infrequent and malignant neoplasm of cutaneous adnexal origin, arising subsequent to follicular differentiation. Clinically, it manifests as a well-circumscribed, solitary lesion, predominantly observed on the scalp. Cylindroma, conversely, is a benign and indolent adne....
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Case Report
Complex maxillofacial injury in an alcoholic-road to reconstruction
Author details: Surendrakumar B Patil, Varsha Suhasrao Barai, Ashish Warhekar, Al-Iqyan Fidvi
Road traffic accidents are the eighth leading cause of death worldwide, with a significant impact on individuals aged 5 to 29 years as per WHO. Traumatic maxillofacial injuries, often resulting from road traffic accidents, account for a substantial proportion of these injuries. Facial reconstruction....
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Extraskeletal myxoid chondrosarcoma of the finger mimicking a glomus Tumour: A rare case scenario
Author details: Sonal Tripathi, Karishma Dhingra, Anshul Singh, Vatsala Misra
Extraskeletal myxoid chondrosarcoma (EMC) is an extremely uncommon soft tissue neoplasm of chondroblastic origin, predominantly seen in middle-aged and elderly individuals and is more prevalent in males.  It exhibits a predilection for the deep soft tissue of proximal extremities and limb girdl....
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Reversible pancytopenia: A diagnostic dilemma
Author details: Somnath Maitra, Kaushik Hazra, Biswaroop Mukherjee, Ipshita Chatterjee
Hydroxychloroquine (HCQS) is a medication initially developed for treatment of malaria. It is used for various rheumatological and skin disorders with various side effects and drug reactions. A 61 years old female presented with fever and pancytopenia with polymorphic skin lesions and sore throat. A....
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Celiac disease presenting as peripheral neuropathy- A rare case report
Author details: Dinkar Yadav, Neha Pruthi, Anjali Verma, Alok Khanna, Neha Yadav
Celiac disease is an autoimmune disorder usually presenting with gastro-intestinal symptoms and very rarely presents as extra gastro-intestinal manifestations like peripheral neuropathy, arthritis and gluten ataxia. This is a case of an 8 year old girl, diagnosed with celiac disease who developed we....
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Non transfusional haemochromatosis in patient of thalassemia minor
Author details: Komal Gharsangi, Pratibha Himral, Gurpreet Sharma
Haemochromatosis as an acquired form is seen in hematological conditions which necessitates chronic blood transfusions. Beta thalassemia minor patients are generally transfusion independent but still can have secondary iron overload like condition which affects heart, liver, pancreas. Our patient wa....
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Leiomyoma of the appendix: A familiar lesion at an unfamiliar location
Author details: Sushma Ramraje, Snehal Chavhan, Diksha Dahake, Shatabdi Ghosh
This report examines the rare case of a 22-year-old male diagnosed with an appendiceal leiomyoma after presenting with abdominal pain and intermittent fever, similar to an episode experienced six months prior mimicking appendicitis. Such leiomyomas are exceptionally rare in medical literature, with....
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Case Series
Histopathological insights into dysgenetic gonads: A comprehensive case series analysis
Author details: Pratiksha Mishra, Meenakshi Mohapatro, Fakir Charan Munda, Liza Das, Phalgunee Priyadarshini, Lity Mohanty
Normal sexual development relies on the synergistic action of numerous activating and repressing factors interacting in a precise spatio temporal environment. Disorders of sex development (DSDs) can be classified into various categories, usually associated with abnormal development of chromosomal, g....
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