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- DOI 10.18231/pjms.v.15.i.2.292-297
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CK-MB and LDH as predictor of HIE in term babies born with perinatal asphyxia
Background: One prevalent issue affecting newborns is perinatal asphyxia, which has a substantial impact on the morbidity and mortality of newborns. Perinatal asphyxia can affect all the organ systems with a higher predilection for the nervous system resulting in neurological dysfunction which has been termed Hypoxic Ischemic Encephalopathy (HIE). It has been discovered that LDH and CK-MB have great sensitivity and specificity and that the results of these tests can be obtained right away at the bedside. Following asphyxia, there is a significant increase in LDH and CK-MB, which indicates that these enzymes may be useful in predicting the degree of hypoxic-ischaemic insult a newborn would experience.
Aims: 1: To evaluate the serum CK-MB and LDH levels among asphyxiated and non-asphyxiated term neonates; 2: To study whether these enzymes (if raised) can be used to predict the development of Hypoxic Ischaemic Encephalopathy (HIE) and its correlation with HIE staging.
Materials and Methods: Newborns with perinatal asphyxia were used as cases in this prospective case-control research, whereas healthy term neonates were used as controls. Blood for CK-MB had been drawn at 8 ± 2hrs. of birth as well as LDH at 72 ± 2 hrs of birth.
Results: When comparing the levels of CK-MB as well as LDH in cases versus controls, a significant p value of 0.001 was obtained. LDH was found to have more sensitivity & specificity than CK-MB and hence was found to have more diagnostic accuracy. Babies that died due to HIE 3 had marked elevation of both biomarker levels as compared to other cases of asphyxia.
Conclusion: 1. LDH at 72±2 hours of birth was found to be a better diagnostic test than CK-MB for detecting HIE in cases of perinatal asphyxia; 2. LDH and CK-MB can be utilized to correlate the degree of HIE in cases of birth asphyxia.
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How to Cite This Article
Vancouver
Hussain J, Deka A, Mahapatra I. CK-MB and LDH as predictor of HIE in term babies born with perinatal asphyxia [Internet]. Panacea J Med Sci. 2025 [cited 2025 Oct 07];15(2):292-297. Available from: https://doi.org/10.18231/pjms.v.15.i.2.292-297
APA
Hussain, J., Deka, A., Mahapatra, I. (2025). CK-MB and LDH as predictor of HIE in term babies born with perinatal asphyxia. Panacea J Med Sci, 15(2), 292-297. https://doi.org/10.18231/pjms.v.15.i.2.292-297
MLA
Hussain, Jesmin, Deka, Anupama, Mahapatra, Ipsita. "CK-MB and LDH as predictor of HIE in term babies born with perinatal asphyxia." Panacea J Med Sci, vol. 15, no. 2, 2025, pp. 292-297. https://doi.org/10.18231/pjms.v.15.i.2.292-297
Chicago
Hussain, J., Deka, A., Mahapatra, I.. "CK-MB and LDH as predictor of HIE in term babies born with perinatal asphyxia." Panacea J Med Sci 15, no. 2 (2025): 292-297. https://doi.org/10.18231/pjms.v.15.i.2.292-297