- Visibility 139 Views
- Downloads 74 Downloads
- Permissions
- DOI 10.18231/pjms.v.15.i.2.269-274
-
CrossMark
- Citation
An observational study to evaluate Loss To Follow-Up (LTFU) rate and treatment outcomes of pulmonary tuberculosis patients in the Dehradun district
- Author Details:
-
Shiv Kumar Yadav *
-
Richa Sinha
-
A R Piyush
-
Dheeraj Gupta
Introduction: Tuberculosis case detection, treatment adherence, and treatment outcomes have significantly improved over the past decade. However, it is essential to identify the ongoing barriers at both grassroots and programmatic levels to enhance these areas, enabling India to move closer to its goal of TB elimination by 2025.
Aim and Objective: This study evaluated the loss to follow-up (LTFU) rate and treatment outcomes among pulmonary tuberculosis patients in the Dehradun district.
Materials and Methods: an observational study carried out using secondary data gathered from tuberculosis patients reported in the Dehradun District during three years (2018-2020). The data collected was analyzed to evaluate treatment results and treatment adherence of the pulmonary tuberculosis patients.
Result: - Among study participants, LTFU rate increased in Chakrata, Dehradun, and Rishikesh in 2020, likely attributed to challenges posed by the COVID-19 pandemic. In contrast, Kalsi exhibited consistently lower loss rates and relatively high positive outcomes, suggesting it could serve as a model for other treatment units. The decline in positive outcomes during the year 2020 at various Tuberculosis Units is in alignment with decreased TB case notification and increased LTFU rates, likely a result of disruptions in the healthcare system and restricted access to tuberculosis services during the pandemic.
Conclusion: The improvement in NTEP indicators, such as tuberculosis treatment adherence and treatment outcomes, indicates that the program is progressing in the right direction. Nevertheless, it remains crucial to address programmatic gaps and expedite efforts in alignment with the national goal of TB elimination by 2025.
References
- Central TB Division, Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India. India TB Report 2018, Government of India, 2018.
- World Health Organization. An expanded DOTS framework for effective tuberculosis control. WHO/CDS/TB/2002.297. Geneva: World Health Organization. 2002. Available at: http://whqlibdoc.who.int/hq/2002/WHO_CDS_TB_2002.297.
- Munro SA, Lewin SA, Smith HJ, Engel ME, Fretheim A, Volmink J. Patient adherence to tuberculosis treatment: A systematic review of qualitative research. PLoS Med. 2007;4(7):e238.
- Mitchison DA. How drug resistance emerges as a result of poor compliance during short-course chemotherapy for tuberculosis. Int J Tuberc Lung Dis. 1998;2(1):10–15.
- Central TB Division, Ministry of Health and Family Welfare. Government of India. Training Modules (1-4) for Programme Managers and Medical Officers. New Delhi, India: Ministry of Health and Family Welfare; 2020.
- Chang SH, Cataldo JK. A systematic review of global cultural variations in knowledge, attitudes and health responses to tuberculosis stigma. Int J Tuberc Lung Dis. 2014;18(2):168–73.
- Hasker E, Khodjikhanov M, Sayfiddinova S, Rasulova G, Yuldashova U, Uzakova G, et al. Why do tuberculosis patients default in Tashkent City, Uzbekistan? A qualitative study. Int J Tuberc Lung Dis. 2010;14:1132–9.
- Mishra P, Sharma RK, Yadav R, Rao VG, Nigam S, Lingala MA, et al. Reasons for loss to follow-up (LTFU) of pulmonary TB (PTB) patients: A qualitative study among Saharia, a particularly vulnerable tribal group of Madhya Pradesh, India. PLoS One. 2021;16(12):e0261152.
- Gler M, Podewils L, Munez N, Galipot M, Quelapio M, Tupasi T. Impact of patient and program factors on default during treatment of multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2012;16(7):955–60.
- Kurbatova EV, Taylor A, Gammino VM, Bayona J, Becerra M, Danilovitz M, et al. Predictors of poor outcomes among patients treated for multidrug-resistant tuberculosis at DOTS-plus projects. Tuberculosis. 2012;92(5):397–403.
- Thomas BE, Subbaraman R, Sellappan S, Suresh C, Lavanya J, Lincy S, et al. Pretreatment loss to follow-up of tuberculosis patients in Chennai, India: a cohort study with implications for health systems strengthening. BMC Infect Dis. 2018;18(1):142.
- Central TB Division, Ministry of Health and Family Welfare, Government of India. India TB Report; 2022
- Kant S, Singh AK, Parmeshwaran GG, Haldar P, Malhotra S, Kaur R. Delay in the initiation of treatment after diagnosis of pulmonary tuberculosis in primary health care setting: Eight-year cohort analysis from district Faridabad, Haryana, North India. Rural Remote Health. 2017;17(3):4158.
- Mundra A, Deshmukh PR, Dawale A. Magnitude and determinants of adverse treatment outcomes among tuberculosis patients registered under revised national tuberculosis control program in a tuberculosis unit, Wardha, Central India: A record-based cohort study. J Epidemiol Glob Health. 2017;7(2):111–8. 274 Yadav et al. / Panacea Journal of Medical Sciences 2025;15(2):269-274
- Khaitan A, Rai SK, Krishnan A, Gupta SK, Kant S, Khilnani GC. Loss-to-follow-up rate among tuberculosis patients registered at two tuberculosis units of Ballabgarh block of district Faridabad, Haryana: A desk review. Indian J Med Spec. 2023;14(2):82–7.
- Singh M, Bahurupi Y, Sharma A, Kishore S, Aggarwal P, Jain B, et al. Treatment outcomes of tuberculosis patients detected by active case finding under the Revised National Tuberculosis Control Programme in 2018 in the Haridwar district of Uttarakhand. J Family Med Prim Care. 2020;9(10):5132–5.
How to Cite This Article
Vancouver
Yadav SK, Sinha R, Piyush AR, Gupta D. An observational study to evaluate Loss To Follow-Up (LTFU) rate and treatment outcomes of pulmonary tuberculosis patients in the Dehradun district [Internet]. Panacea J Med Sci. 2025 [cited 2025 Oct 27];15(2):269-274. Available from: https://doi.org/10.18231/pjms.v.15.i.2.269-274
APA
Yadav, S. K., Sinha, R., Piyush, A. R., Gupta, D. (2025). An observational study to evaluate Loss To Follow-Up (LTFU) rate and treatment outcomes of pulmonary tuberculosis patients in the Dehradun district. Panacea J Med Sci, 15(2), 269-274. https://doi.org/10.18231/pjms.v.15.i.2.269-274
MLA
Yadav, Shiv Kumar, Sinha, Richa, Piyush, A R, Gupta, Dheeraj. "An observational study to evaluate Loss To Follow-Up (LTFU) rate and treatment outcomes of pulmonary tuberculosis patients in the Dehradun district." Panacea J Med Sci, vol. 15, no. 2, 2025, pp. 269-274. https://doi.org/10.18231/pjms.v.15.i.2.269-274
Chicago
Yadav, S. K., Sinha, R., Piyush, A. R., Gupta, D.. "An observational study to evaluate Loss To Follow-Up (LTFU) rate and treatment outcomes of pulmonary tuberculosis patients in the Dehradun district." Panacea J Med Sci 15, no. 2 (2025): 269-274. https://doi.org/10.18231/pjms.v.15.i.2.269-274