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- DOI 10.18231/pjms.v.15.i.2.275-279
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Elevated inflammatory markers in pre-diabetic individuals: correlation with hs-CRP & implications for cardiovascular disease prevention
Background: Pre-diabetes is a condition characterized by elevated blood glucose levels that fall below the diagnostic thresholds for diabetes. It is a precursor to Type 2 diabetes and is associated with an increased risk of cardiovascular diseases (CVD) due to systemic inflammation. Inflammatory markers such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) are known to play critical roles in the progression of insulin resistance and subsequent disease development.
Aim & Objective: To evaluate the association of inflammatory markers, including TNF-α, IL-6, and hs-CRP, with insulin resistance in pre-diabetic individuals compared to normoglycemic controls.
Materials and Methods: This study involved 60 pre-diabetic individuals and a normoglycemic control group. Insulin resistance was assessed using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Serum levels of TNF-α, IL-6, and hs-CRP were measured to evaluate systemic inflammation. Statistical analysis was conducted to determine the correlation between HOMA-IR and inflammatory markers, as well as the interrelationships among the markers.
Results: The study found a strong positive correlation between HOMA-IR and TNF-α (r = 0.925), as well as HOMA-IR and IL-6 (r = 0.766). A significant relationship was also observed between TNF-α and hs-CRP (r = 0.831), highlighting elevated systemic inflammation in pre-diabetic individuals.
Conclusion: The findings indicate that systemic inflammation plays a critical role in the progression of pre-diabetes to Type 2 diabetes and CVD. Inflammatory markers such as TNF-α, IL-6, and hs-CRP can serve as early indicators of disease progression. Early detection and targeted interventions focused on reducing inflammation may help prevent the transition from pre-diabetes to diabetes and mitigate cardiovascular risks, thereby improving patient outcomes.
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How to Cite This Article
Vancouver
Lahiri S. Elevated inflammatory markers in pre-diabetic individuals: correlation with hs-CRP & implications for cardiovascular disease prevention [Internet]. Panacea J Med Sci. 2025 [cited 2025 Oct 07];15(2):275-279. Available from: https://doi.org/10.18231/pjms.v.15.i.2.275-279
APA
Lahiri, S. (2025). Elevated inflammatory markers in pre-diabetic individuals: correlation with hs-CRP & implications for cardiovascular disease prevention. Panacea J Med Sci, 15(2), 275-279. https://doi.org/10.18231/pjms.v.15.i.2.275-279
MLA
Lahiri, Soma. "Elevated inflammatory markers in pre-diabetic individuals: correlation with hs-CRP & implications for cardiovascular disease prevention." Panacea J Med Sci, vol. 15, no. 2, 2025, pp. 275-279. https://doi.org/10.18231/pjms.v.15.i.2.275-279
Chicago
Lahiri, S.. "Elevated inflammatory markers in pre-diabetic individuals: correlation with hs-CRP & implications for cardiovascular disease prevention." Panacea J Med Sci 15, no. 2 (2025): 275-279. https://doi.org/10.18231/pjms.v.15.i.2.275-279