- Visibility 44 Views
- Downloads 26 Downloads
- Permissions
- DOI 10.18231/pjms.v.15.i.2.373-377
-
CrossMark
- Citation
Histopathological study of lung malignancies on small biopsies - A tertiary care experience in Central India
Introduction: Lung cancer accounts for 5.9% of all cancer cases and 8.1% of cancer-related deaths in India. In patients with advanced lung malignancies, CT‐guided needle biopsy (CTNB) was conducted as they are less invasive and are preferrable to resection to make a pathological diagnosis.
Materials and Methods: Lung malignancies were diagnosed on small biopsies in the Department of Pathology during the period of January 2021 to December 2022, at a tertiary care hospital in state of Maharashtra in India. A retrospective, observational study was conducted on 82 patients with radiologically proven lung malignancies. Amongst 82 cases, 06 cases were inadequate for interpretation and hence excluded from the study. Biopsies were conducted for all cases. Tissue cores of approximate length 1- 1.5 cm were received in 10% formalin in histopathology section which were processed routinely and stained with haematoxylin and eosin stains. Biopsy specimen was considered adequate when it contained more than 20 alveoli.
Results: The histopathological analysis of these specimens showed Adenocarcinoma (36.84%) as the most common lung tumour closely followed by squamous cell carcinoma (34.21%) Subtypes of adenocarcinoma noted included solid pattern (n= 18, 64.29%), acinar pattern (n= 04, 14.29%), mucinous pattern (n= 03, 10.71%) and micropapillary pattern (n= 03, 10.71%). Small cell carcinoma accounted for 15.79% of all cases followed by non-small cell carcinoma (n= 04, 5.26%) adenosquamous carcinoma (n= 03, 3.95%), and metastasis (n= 03, 3.95%).
Conclusion: Due to the advanced nature of presentation and unresectable nature of malignancies in majority of lung cancers, diagnosis of lung tumours heavily relies on small biopsies.
References
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
- Mohan A, Garg A, Gupta A, Sahu S, Choudhari C, Vashistha V, et al. Clinical profile of lung cancer teil North India: A 10-year analysis of 1862 patients from a tertiary care center. Lung India. 2020;37:190–7.
- Shabnam S, Rahul G, Subhash B. Histopathological Patterns of Endobronchial Lung Biopsy Specimen in Lung Cancer along with Clinico - Radiological Correlation. Int J Contemp Med Res. 2018;5(1):1–5.
- Kage H, Kohsaka S, Shinozaki‐Ushiku A, Hiraishi Y, Sato J, Nagayama K, et al. Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing. Cancer Sci. 2019;110(8):2652–7.
- Roy-Chowdhuri S. Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies: Guidelines from the College of American Pathologists (CAP). J Mol Pathol. 2021;2(1):23–8.
- Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. WHO Classification of Tumours of the Lung, Pleura, Thymus and HeartLyon: IARC. 2015
- Krishnamurthy A, Vijaylakshmi R, Gadigi V, Rangananathan R, Sagar T. The relevance of “ Nonsmoking- associated lung cancer” Kolhe et al./ Panacea Journal of Medical Sciences 2025;15(2):373-377 377 in India. A single-center experience. Indian J Cancer. 2012;49(1):82–8.
- Malik PS, Sharma MC, Mohanti BK, Shukla NK, Deo SVS, Mohan A, et al.: Clinico-pathological profile of lung cancer at AIIMS: A changing paradigm in India. Asian Pac J Cancer Prev. 2013;14(1):489–94.
- Noronha V, Dikshit R, Raut N, Joshi A, Pramesh CS, George K, et al. Epidemiology of lung cancer in India: Focus on the differences between non-smokers and smokers: A single-centre experience. Indian J Cancer. 2012;49(1):74–81.
- Khaparde SH, Patrike SB, Deshmukh SD, Shinde BB: Role of needle biopsy in early diagnosis of lung lesions in tertiary care hospital. IP J Diagn Pathol Oncol. 2021;6(3):170–4.
- Nicholson Andrew G, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, et al. The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015. J Thoracic Oncol. 2022;17(3):362–87.
- Sundaram V, Sanyal N. Clinicopathological profile of bronchogenic carcinoma in a tertiary care hospital in eastern part of India. Clin Cancer Investig J. 2014;3(3):220–4.
- Kulshrestha R, Menon BK, Vijayan VK. Role of a pattern based approach in interpretation of transbronchoscopic lung biopsy and its clinical implications. Indian J Chest Dis Allied Sci. 2012;54(1):9–
- Gupta R, Chowdary I, Singh P. Clinical, radiological and histological profile of primary lung carcinomas. JK Sci. 2015;17(3):146–51.
- Mandal SK, Singh TT, Sharma TD, Amrithalingam V. Clinico- pathology of lung cancer in a regional cancer centre in Northeastern India. Asian Pac J Cancer Prev. 2013;14(12):7277–81.
- Lambe G, Durand M, Buckley A, Nicholson S, McDermott R. Adenocarcinoma of the lung: from BAC to the future. Insights Imaging. 2020;11(1):69.
- Cao L, Li ZW, Wang M, Ting-Ting Z, Bo B, Yun-Peng L. Clinicopathological characteristics, treatment and survival of pulmonary large cell neuroendocrine carcinoma: a SEER population-based study. Peer J. 2019;7:6539.
- Oshiro Y, Kusumoto M, Matsuno Y, Asamura H, Tsuchiya R, Terasaki H, et al.: CT findings of surgically resected large cell neuroendocrine carcinoma of the lung in 38 patients. AJR Am J Roentgenol. 2004;182(1):87–91.
- Tai Q, Zhang L, Hu X. Clinical characteristics and treatments of large cell lung carcinoma: a retrospective study using SEER data. Transl Cancer Res. 2020;9(3):1455–64.
- Battafarano RJ, Fernandez FG, Ritter J, Meyers BF, Guthrie TJ, Cooper JD, et al. Large cell neuroendocrine carcinoma: an aggressive form of non-small cell lung cancer. J Thorac Cardiovasc Surg. 2005;130(1):166–72.
- Lewis DR, Check DP, Caporaso NE, Travis WD, Devesa SS. US lung cancer trends by histologic type. Cancer. 2014;120(18):2883–
- Raso MG, Bota-Rabassedas N, Wistuba II. Pathology and Classification of SCLC. Cancers. 2021;13(4):820.
- Li, Chenghui L, Hongyang L. Adenosquamous carcinoma of the lung. Onco Targets Ther. 2018:11:4829–35.
How to Cite This Article
Vancouver
Kolhe AP, Gaikwad A, Bode A, Patil RP, Kowe B. Histopathological study of lung malignancies on small biopsies - A tertiary care experience in Central India [Internet]. Panacea J Med Sci. 2025 [cited 2025 Oct 07];15(2):373-377. Available from: https://doi.org/10.18231/pjms.v.15.i.2.373-377
APA
Kolhe, A. P., Gaikwad, A., Bode, A., Patil, R. P., Kowe, B. (2025). Histopathological study of lung malignancies on small biopsies - A tertiary care experience in Central India. Panacea J Med Sci, 15(2), 373-377. https://doi.org/10.18231/pjms.v.15.i.2.373-377
MLA
Kolhe, Ankita Piyush, Gaikwad, Amrapali, Bode, Anjali, Patil, Rekha Patil, Kowe, Balwant. "Histopathological study of lung malignancies on small biopsies - A tertiary care experience in Central India." Panacea J Med Sci, vol. 15, no. 2, 2025, pp. 373-377. https://doi.org/10.18231/pjms.v.15.i.2.373-377
Chicago
Kolhe, A. P., Gaikwad, A., Bode, A., Patil, R. P., Kowe, B.. "Histopathological study of lung malignancies on small biopsies - A tertiary care experience in Central India." Panacea J Med Sci 15, no. 2 (2025): 373-377. https://doi.org/10.18231/pjms.v.15.i.2.373-377