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- DOI 10.18231/pjms.v.15.i.2.428-432
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CrossMark
A case control study to assess clinical and lipid profile in patients with xanthelasma palpebrarum in a tertiary care centre
- Author Details:
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Mahanthesh P
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Sachin Somashekhar
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Hrishikesh Shivakumar
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Anugraha Durairaj *
Sachin Somashekhar
Hrishikesh Shivakumar
Anugraha Durairaj *
Background: Xanthelasma palpebrarum is used to describe xanthoma that occurs on the eyelids or inner canthi of the eyes. It is frequently associated with cardiovascular disease, diabetes, obesityetc. Various authors have found a positive relationship between xanthelasma palpebrarum and lipid profile.
Objective: Xanthelasma palpebrarum is a common condition observed in dermatology OPD for the cosmetic problem posed by it. Most of these patients would not have undergone a lipid profile and there is a need to know whether lipid profile is mandatory for all the patients presenting with xanthelasma palpebrarum. Hence this study was undertaken
Materials and Methods: In this case-control study, 55 subjects diagnosed with xanthelasma palpebrarum and 55 healthy controls were chosen. All cases and controls underwent detailed clinical examination and fasting lipid profile study.
Results: Total cholesterol levels were found increased in 36 cases (65.5%) in contrast to 20 controls (36%) with p=0.004(highly significant).Increase in LDL cholesterol levels were found in 31 cases (56.4%) as against 15 controls (27%) making it statistically significant (p= 0.001). Other cholesterol fractions were not found to have a significant relationship.
Conclusion: At the end of this study it was observed that there is a significant elevation in total cholesterol and LDL cholesterol in xanthelasma patients as compared to controls, thereby making lipid profile study mandatory for all patients.
References
- Gangopadhyay DN, Dey SK, Mitra C, Pal D, Chaudhuri S. Serum lipid profile in Xanthelasma palpebrum. Ind J Dermatol. 1998;43(2):53–7. 432 Mahanthesh et al/ Panacea Journal of Medical Sciences 2025;15(2):428-432
- Bergman R. The pathogenesis and clinical significance of xanthelasma palpebrarum. J Am Acad Dermatol. 1994;30(2 Pt 1):236–42.
- Jain A, Goyal P, Nigam PK, Gurbaksh H, Sharma RC. Xanthelasma palpebrarum-clinical and biochemical profile in a tertiary care hospital of Delhi. Indian J Clin Biochem. 2007;22(2):151–3.
- Haque MU, Ramesh V. Evaluation of three different strengths of trichloroacetic acid in xanthelasma palpebrarum. J Dermatolog Treat. 2006;17(1):48–50.
- Ozdöl S, Sahin S, Tokgözoğlu L. Xanthelasma palpebrarum and its relation to atherosclerotic risk factors and lipoprotein (a). Int J Dermatol. 2008;47(8):785–9.
- Bates MC, Warren SG. Xanthelasma: clinical indicator of decreased levels of high-density lipoprotein cholesterol. South Med J. 1989;82(5):570–4.
- Epstein NN, Rosenman RH, Gofman JW. Serum lipoproteins and cholesterol metabolism in xanthelasma. AMA Arch Derm Syphilol. 1952;65(1):70–81.
- Pedace FJ, Winkelmann RK. Xanthelasma palpebrarum. JAMA. 1965;193:893–4.
- Chhetri MK, Chowdhury ND, De B. Xanthelasma palpebrarum: an analysis of 141 cases. J Assoc Physicians India. 1967;15:405–12.
- Dey A, Aggarwal R, Dwivedi S. Cardiovascular profile of Xanthelasma palpebrarum. Biomed Res Int. 2013;2013:932863.
- Marcelo GH, Janis PM. Xanthelasma. 2005 May 12. Available from: URL: eMedicine Specialties.
- Reddy BSN, Singh G, Pandey SS, Tiwari D. Clinical and lipid profile studies in Xanthelasma palpebrarum. Indian J Dermatol Venereol Leprol. 1983;49(3):127–31.
- Vacca JB, Knight WA Jr, Broun GO Sr. Clinical observations regarding xanthelasma. Ann Intern Med. 1959;51:1019–31.
- Ribera M, Pintó X, Argimon JM, Fiol C, Pujol R, Ferrándiz C. Lipid metabolism and apolipoprotein E phenotypes in patients with xanthelasma. Am J Med. 1995;99(5):485–90.
- Kavoussi H, Ebrahimi A, Rezaei M, Ramezani M, Najafi B, Kavoussi R. Serum lipid profile and clinical characteristics of patients with xanthelasma palpebrarum. An Bras Dermatol. 2016;91(4):468–71.
- Tursen U, Eskandari G, Kaya TI, Tamer L, Ikizoglu G, Atik U. Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients. J Eur Acad Dermatol Venereol. 2006;20(3):260–3.
- Kahán A, Kahán IL, Timár V. Lipid anomalies in cases of xanthelasma. Am J Ophthalmol. 1967;63(2):320–5.
- Watanabe A, Yoshimura A, Wakasugi T, Tatami R, Ueda K, Ueda R, et al. Serum lipids, lipoprotein lipids and coronary heart disease in patients with xanthelasma palpebrarum. Atherosclerosis. 1981;38(3- 4):283–90.
- Mannino G, Papale A, De Bella F, Mollo R, Morgia P, Gabrieli CB. Use of Erbium:YAG laser in the treatment of palpebral xanthelasmas. Ophthalmic Surg Lasers. 2001;32(2):129–33.
- Fusade T. Treatment of xanthelasma palpebrarum by 1064-nm Q- switched Nd:YAG laser: a study of 11 cases. Br J Dermatol. 2008;158(1):84–7.
- Vermeer BJ, Mateysen AA, van Gent CM, van Sabben RM, Emeis JJ. The lipid composition and localization of free and esterified cholesterol in different types of xanthomas. J Invest Dermatol. 1982;78(4):305–8.
- Sharma SB, Dwivedi S, Prabhu KM, Kumar N, Baruah MC. Preliminary studies on serum lipids, apolipoprotein-B and oxidative stress in xanthelasma. Indian J Clin Biochem. 1999;14(2):245–8.