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- DOI 10.18231/pjms.v.15.i.2.491-493
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CrossMark
Reversible pancytopenia: A diagnostic dilemma
- Author Details:
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Somnath Maitra *
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Kaushik Hazra
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Biswaroop Mukherjee
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Ipshita Chatterjee
Somnath Maitra *
Hydroxychloroquine (HCQS) is a medication initially developed for treatment of malaria. It is used for various rheumatological and skin disorders with various side effects and drug reactions. A 61 years old female presented with fever and pancytopenia with polymorphic skin lesions and sore throat. After exclusion of the common causes, a diagnosis of HCQS induced pancytopenia was made which is a rare side effect of HCQS. The pancytopenia improved following stopping HCQS and the case was diagnosed after detailed history and examination and considering the differentials.
The importance of the case lies in the fact that clinicians should consider drug induced pancytopenia, as it is a reversible cause and can be diagnosed with ease after stopping the offending drug.
References
- EA Shippey, Wagler VD, Collamer AN. Hydroxychloroquine: an old drug with new relevance. Cleveland Clin J Med. 2018;85(6):459–
- E Schrezenmeier, Dorner T. Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020;16(3):155–66.
- Lui J, Cao R, Xu M, Xi W, Huanyu Z, Hengrui H, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is eAective in inhibiting SARSCoV-2 infection in vitro. Cell Disc. 2020;6(16):1–4.
- Zanel GD, Zhanel MA, Boreskie KF, Lynch-III JP, Karlowsky JA. Risk versus benefit of using hydroxychloroquine to treat patients with COVID 19. Can J Infect Dis Med Microbiol. 2021;21:5942366.
- Vargas-Carretero CJ, Fernandez-Vargas OE, Ron-Magaña AL, Padilla-Ortega JA, Ron-Guerrero CS, Barrera-Chairez E. Etiology and clinico-hematological profile of pancytopenia: experience of a Mexican Tertiary Care Center and review of the literature. Hematology. 2019;24(1):399–404.
- Das MK, Kumar MB, Arain S, Kumar S, Kumari S, Vikash. The common causes leading to pancytopenia in patients presenting to tertiary care hospital. Pak J Med Sci. 2013;29(5):1108–11.
- Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital. BMC Hematol. 2013;13(1):10.
- Khunger JM, Arulselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia-A clinico haematological study of 200 cases. Indian J Pathol Microbiol. 2002;45(3):375–9.
- Vargas-Carretero CJ, Fernandez-Vargas OE, Ron-Magaña AL, Padilla-Ortega JA, Ron-Guerrero CS, Barrera-Chairez E. Etiology and clinico-hematological profile of pancytopenia: experience of a Mexican Tertiary Care Center and review of the literature. Hematology. 2019;24(1):399–404.
- Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital. BMC Hematol. 2013;13(1):10.
- Waller DG, Renwick AG, Hillier K. Medical Pharmacology and therapeutics. Second edition. Edinburgh: Elsevier Saunders; 2005.
- Mcduffie FC. Bone marrow depression after drug therapy in patients with systemic lupus erythematosus. Ann Rheum Dis. 1965;24:289–
- Chernof D, Taylor KS. Hydroxychloroquine -induced agranulocytosis. Arch Dermatol. 1968;97(2):163–4.
- Sindhu CB, George S, Sankar A, Stephen V. Hydroxychloroquine review. J Skin Sex Transmitted Dis. 2021;3(1):33–9.
- Shippey EA, Wagler VD, Collamer AN. Hydroxychloroquine: An old drug with new relevance. Cleve Clin J Med. 2018;85(6):459–67.