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- DOI 10.18231/pjms.v.15.i.2.488-490
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Extraskeletal myxoid chondrosarcoma of the finger mimicking a glomus Tumour: A rare case scenario
Extraskeletal myxoid chondrosarcoma (EMC) is an extremely uncommon soft tissue neoplasm of chondroblastic origin, predominantly seen in middle-aged and elderly individuals and is more prevalent in males. It exhibits a predilection for the deep soft tissue of proximal extremities and limb girdles. It is a rare tumour with distinct histology and a characteristic chromosomal translocation, usually t (9;22) (q22;q12.2), fusing EWSR1 to NR4A3. Despite its nomenclature, EMC exhibits no genuine hyaline cartilaginous differentiation and is classified as a tumour of uncertain differentiation in the WHO classification. Histologically, it exhibits myxoid/reticular histology, necessitating immunohistochemistry to aid in its diagnosis. However, molecular methods like fluorescence in-situ hybridization (FISH) are necessary to obtain a definitive diagnosis. In this instance, we detail an uncommon example of an EMC developing in the finger of a middle-aged female that was clinically thought to be a glomus tumour. Owing to its rare presentation, aggressive nature and tendency to recur, a high index of suspicion by a pathologist is required to diagnose this tricky entity, which can otherwise be readily missed.
References
- Enzinger FM, Shiraki M. Extraskeletal myxoid chondrosaroma. An analysis of 34 cases. Hum Pathol. 1972;3(3):421–35.
- Sandberg AA. Genetics of chondrosarcoma and related tumors. Curr Opin Oncol. 2004;16 (4):342–54.
- Stacchiotti S, Baldi GG, Morosi C, Tos APD, Gronchi A. Extraskeletal Myxoid Chondrosarcoma: State of the Art and Current Research on Biology and Clinical Management. Cancers (Basel). 2020 Sep 21;12(9):2703.
- Antonescu CR, Bridge JA, Cunha IW, Dei Tos AP, Fletcher CDM, Folpe AL, et al. WHO classification of tumours of soft tissue and bone, 5 TH Edition. Switzerland. International Agency for research on cancer ( IARC); 2020. Available from: https://www.iarc.who.int/news-events/publication-of-the-who- classification-of-tumours-5th-edition-volume-3-soft-tissue-and- bone-tumours/.
- Goldblum JR, Folpe AL, Malignant soft tissue tumours of uncertain type. In: Weiss SW. Enzinger and Weiss´s soft tissue tumors. 6th edition. Philadelphia: Elsevier; 2014.
- Rao P, Colen RR, Bruner JM, Meis JM. Extraskeletal Myxoid Chondrosarcoma Presenting as an Intradural Spinal Mass: Report of a Rare Clinical Presentation with an Emphasis on Differential Diagnostic Considerations. Rare Tumors. 2014;6(4):5586.
- Mentzel T, Hügel H, Kutzner H. CD34-positive glomus tumor: clinicopathologic and immunohistochemical analysis of six cases with myxoid stromal changes. J Cutan Pathol. 2002 ;29 (7):421–5.
- Folpe AL, Weiss SW. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol. 2003;27(4):421–31.
- Bishop AJ, Bird JE, Conley AP, Roland CL, Moon BS, Satcher RL, et al. Extraskeletal Myxoid Chondrosarcomas: Combined Modality Therapy with Both Radiation and Surgery Improves Local Control. Am J Clin Oncol. 2019;42(10):744–8.
- Drilon DA, Popat S, Bhuchar G, D'Adamo DR, Keohan ML, Fisher C, et al. Extraskeletal myxoid chondrosarcoma: A retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy. Cancer 2008; 113(12):3364–71
- Brown JM, Rakoczy K, Pretell-Mazzini J. Extraskeletal myxoid chondrosarcoma: Clinical features and overall survival. Cancer Treat Res Commun. 2022;31:100530.
How to Cite This Article
Vancouver
Tripathi S, Dhingra K, Singh A, Misra V. Extraskeletal myxoid chondrosarcoma of the finger mimicking a glomus Tumour: A rare case scenario [Internet]. Panacea J Med Sci. 2025 [cited 2025 Oct 07];15(2):488-490. Available from: https://doi.org/10.18231/pjms.v.15.i.2.488-490
APA
Tripathi, S., Dhingra, K., Singh, A., Misra, V. (2025). Extraskeletal myxoid chondrosarcoma of the finger mimicking a glomus Tumour: A rare case scenario. Panacea J Med Sci, 15(2), 488-490. https://doi.org/10.18231/pjms.v.15.i.2.488-490
MLA
Tripathi, Sonal, Dhingra, Karishma, Singh, Anshul, Misra, Vatsala. "Extraskeletal myxoid chondrosarcoma of the finger mimicking a glomus Tumour: A rare case scenario." Panacea J Med Sci, vol. 15, no. 2, 2025, pp. 488-490. https://doi.org/10.18231/pjms.v.15.i.2.488-490
Chicago
Tripathi, S., Dhingra, K., Singh, A., Misra, V.. "Extraskeletal myxoid chondrosarcoma of the finger mimicking a glomus Tumour: A rare case scenario." Panacea J Med Sci 15, no. 2 (2025): 488-490. https://doi.org/10.18231/pjms.v.15.i.2.488-490