Pattern of histopathological diagnosis of lymph node biopsies at a tertiary care hospital in Northeast India

Kasturi Krishnatreya, Mondita Borgohain, Jayanta Kr. Das

Abstract


Biopsy and histopathology plays an important role in establishing the cause of lymphadenopathy. Knowledge of the characteristic histopathological findings and causes of lymphadenopathy may spare patients from unnecessary and management. To study the most frequent cause of enlarged lymph nodes in our set up. To assess the spectrum of lymphadenopathy in various age groups. The study was a hospital based cross-sectional study. Total 75 numbers of patients from July 2015 till June 2016 were recruited. All specimens of lymph node biopsies damaged specimens, known cases were excluded. The diagnosis of was made on the basis of gross morphology and light microscopic features. Ziehl Neelson staining, immunohistochemistry were done whenever required. There were more male cases. Most frequently affected age group was between 40-49 years. The cervical region was most commonly affected. Benign cases were more common. Out of 44 benign cases, 55 % were reactive hyperplasia, 43% were granulomatous lesions and Castleman’s disease in 1 case. Tubercular lymphadenitis was the most frequent entity among granulomatous lesions. Of 31 malignant lesions, 55% were non-hodgkin’s lymphoma 26% were hodgkin’s lymphoma and 19% were metastatic. Lymph node biopsy remains a valuable diagnostic tool as it allows for the architecture of the gland to be viewed thereby given an accurate and concise diagnosis with minimal risk to the patient.

Keywords: Histopathology, Immunohistochemistry, Lymphadenopathy


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