A study of factors associated with raised C reactive protein levels in patients with chronic obstructive pulmonary disease

Ashok Kumar Gudagunti, Afaq Ahmed, Sudhir Chaudhri, Veena H N

Abstract


Background: C-reactive protein (CRP) is used to predict the prognosis of patients with COPD. It has been observed that the degree of obstruction in the airflow is related with the levels of CRP.
Objective: To study factors associated with raised C reactive protein (CRP) levels in patients with chronic obstructive pulmonary disease
Materials and Methods: The present study was Hospital based cross-sectional study among 47 subjects with stable chronic obstructive pulmonary disease (COPD). Detailed history, thorough clinical examination was carried out. Body mass index (BMI), Six minute walk distance test (6MWD) was performed, forced
expiratory volume in 1 second (FEV1% Pred), arterial oxygen tension (PaO2) and smoking status (no. of pack years) was assessed for subjects
Results: The prevalence of raised CRP was significantly more in those with 6MWD with <450 meters compared to those with 6MWD of >450 meters. The prevalence of raised CRP was significantly more in those with FEV1% Predicted <30–50 compared to those with FEV1% Predicted 51-100. The proportion
raised CRP was significantly more in those having PaO2 (mmHg) <60-70 compared to those with PaO2 (mmHg) 71-100. Underwent had raised CRP compared to only normal weight cases. Prevalence of raised CRP was 87.5% among those who smoked more than five pack years of cigarette compared to
only 50% but this association was not found to be statistically significant (p>0.05).
Conclusion: Serum CRP levels were significantly associated with 6MWD test, BMI, FEV1% Predicted and PaO2 in patients with stable COPD. But it was not associated with smoking.

Keywords: C reactive proteins COPD smoking six minute walk distance
body mass index


Full Text:

PDF