Clinicopathological profile of AKI in children in a tertiary health centre

Shantisena Mishra, Saiprasanna Behera

Abstract


Background: In view of the magnitude of AKI problem and the changing scenario concerning the age composition, etiological pattern, clinical manifestations and benefit of early detection and appropriate management, this particular study was undertaken to analyse the various aspects of AKI in children in our setup.
Objectives: To determine the etiology, clinical profile, incidence & short term outcomes in hospitalized children aged 1 month to 14 years with acute kidney injury (AKI). 
Materials and Methods: This prospective observational study was conducted in the pediatric wards of a tertiary hospital in southern Odisha, to study etio – clinical profile of AKI (defined according to the acute kidney injury network criteria). From October 2017 to September 2019, 201 children were included in the study.
Results: The incidence of AKI was 1% in the pediatric wards. AKI occurred commonly in association with malaria (41.8%) followed by sepsis (21.4%), snake bite (14.9%), acute gastroenteritis (9%) & acute glomerulonephritis (5.5%), nephrotic syndrome (3%). Most presenting feature is oliguria/anuria (86%) followed by fever (67.2%), loose stool (16.9%), H/O snake bite (14.9%). Dialysis was required in 34.3%; mortality was 12.9%.
Conclusions: The incidence of AKI is more common in age group 5 – 10 yr, males being affected more. Intrinsic renal mechanism was commonest mode of AKI.

Keywords: Acute kidney injury, Hospitalized children, Incidence, Peritoneal dialysis, Serum creatinine.


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