Gall bladder dysfunction in correlation with autonomic neuropathy in type 2 diabetes

Rakesh Raje Urs M C

Abstract


Introduction: Diabetic Autonomic Neuropathy (DAN) is one of the complications of diabetes mellitus causing impaired autonomic control over cardiovascular, gastrointestinal systems. There is increased incidence of gallbladder diseases in diabetic patients attributed to gallbladder dysfunction caused by autonomic neuropathy. This study is undertaken to support the evidence of gall bladder dysfunction can be considered as indicator of autonomic neuropathy in type 2 diabetes mellitus.
Aim: To study the gall bladder ejection fraction in Type 2 diabetics and comparison of gall bladder ejection fraction in diabetics with healthy control group.
Materials and Methods: 100 Type 2 diabetics and 20 healthy controls were taken for study. Subjects cardiac autonomic tests and laboratory investigations were done. Gallbladder volumes (fasting and postprandial) and ejection fraction were considered.
Results: Mean gall gladder volumes (fasting and post prandial) was higher in subjects with Type 2 diabetes compared to control group. Mean gall bladder ejection fraction was lower in subjects with diabetes as compared to controls difference was not significant (p < 0.45). Mean gall bladder volumes (fasting and post prandial) was increased in Type 2 diabetics with CAN compared to Type 2 diabetics without CAN. Mean gall bladder ejection fraction was decreased in Type 2 diabetics with CAN compared to Type 2 diabetics without CAN difference was statistically significant (p < 0.00037).
Conclusion: Thus from the study can conclude that gallbladder dysfunction involving gastrointestinal system can be taken as indicator of autonomic neuropathy in diabetes.

Keywords: Cardiac Autonomic Neuropathy, Gall bladder dysfunction, Type 2 Diabetes Mellitus.


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