A study of left ventricular diastolic dysfunction in prehypertensive middle aged indiviuais

P Venkatesh, S. Vithiavathi, Gerard Joseph Devadassou

Abstract


Prehypertension is associated with excessive morbidity and mortality due to Cardiovascular diseases (CVD). Our study emphasizes the need of early diagnosis of left ventricular diastolic dysfunction in prehypertension patients and to perform echocardiogram in prehypertension middle aged patients.

Materials and Methods: Its hospital based cross sectional study done on 50 samples all middle aged patients of both sexes with prehypertension in the age group of 45-64years.

Results: The mean E value was found to be 69.78+4.83, mean value of A was 68.88+5.71 and mean value of E/A 1.01+.0.15. About 17(34%) had normal diastolic function E/A Ratio between 1.0-1.5 and 33 (66%) had impaired relaxation grade 1. There is no significant difference between the smokers and non – smokers, likewise for obese and non -obese patients.

Conclusion: We conclude that even non obese patients and non- smokers has significant diastolic dysfunction, so prehypertension is risk factor for diastolic dysfunction.

Keywords: Prehypertension, Diastolic dysfunction, Echocardiogram, Cardiovascular disease.



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References


Jang SY, Kim S, Lee CK, Cho EJ, Cho SJ, Lee SC. Prehypertension and Left Ventricular Diastolic Dysfunction in Middle-Aged Koreans Korean Circ J. 2016;46(4)536.

Santos ABS, Gupta DK, Bello NA, Gori M, Claggett B, Fuchs FD, et al. Prehypertension is associated with abnormalities of cardiac structure and function in the atherosclerosis risk in communities study. Am J Hypertens. 2016;29(5):568-74.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. National heart, lung, and blood institute joint national committee on prevention, detection, evaluation, and treatment of high blood pressure; national high blood pressure education program coordinating committee. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289:2560-72.

Yadav S, Bodddula R. Prevalence and risk factors of prehypertension and hypertension in an affluent north Indian population. Indian J Med Res. 2008;128(6):712-20.

Vasan RS, Larson MG, Leip EP, Kannel WB, Levy D. Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet. 2001;358(9294):1682-6.

KC Ferdinand, RS Pacini. New evidence confirms risks associated with prehypertension and benefits of therapeutic lifestyle changes in management. J Cardiometabolic Syndr. 2007;2(4):302-4.

Alam M, Samad BA, Wardell J, Andersson E, Hoglund C, Nordlander R. Acute effects of smoking on diastolic function in healthy participants: Studies by conventional Doppler echocardiography and doppler tissue imaging. J Am Soc Echocardiogr. 2002;15:1232-7.

Eroglu E, Aydin S, Yalniz F, Kalkan AK, Bayrak F, Degertekin M. Chronic cigarette smoking affects left and right ventricular long-axis function in healthy young subjects: A Doppler myocardial imaging study. Echocardiogr. 2009;26:1019-25.

Galderisi M, Petrocelli A, Alfieri A. Impact of ambulatory blood pressure on left ventricular diastolic function in uncomplicated arterial systemic hypertension. Am J Cardiol. 1996;77:597-601.

Zabalgoitia M, Rahman NU, Haley W. Disparity between diastolic mitral flow characteristics and left ventricular mass in essential hypertension. Am J Cardiol.1997;79:1255-8.

Giorgi D, Di Bello V, Pedrinelli R, Bertini A, Talini E, Dell’Omo G, et al. Ultrasonic tissue characterization and Doppler tissue imaging in the analysis of left ventricular function in essential arterial hypertension: a preliminary study. Echocardiogr. 2002;19:187-98.

Ahn HS, Kim SJ, Kim MK. The difference of left ventricular hypertrophy and the diastolic function between prehypertensive and normotensive. Korean Circ J. 2006;36:437-42.

Erdogan D, Caliskan M, Yildirim I. Effects of normal blood pressure, prehypertension and hypertension on left ventricular diastolic function and aortic elastic properties. Blood Press. 2007;16:114-21.

Almuntaser I, Mahmud A, Brown A. Blood pressure control determines improvement in diastolic dysfunction in early hypertension. Am J Hypertens. 2009;22:1227-31.

Erdogan D, Caliskan M, Gullu H. Aortic elastic properties and left ventricular diastolic function in white-coat hypertensive individuals. Blood Press Monit. 2006;11:191-8.