A study of the correlation between mean platelet volume and diabetic retinopathy in patients with type 2 diabetes mellitus

Yeruva Poulina Deepth Reddy, S Vithiavathi, G. Kalaiselvi

Abstract


Diabetic retinopathy (DR), a kind of micro vascular lesion that is detected on fundus examination, accounts for 40 percent of diabetics over 40 years of age. To determine the correlation of mean platelet volume with diabetic retinopathy.

Methodology: Hospital based Case- Control study. 50 patients diagnosed as Type-2 diabetes mellitus with defined diabetic retinopathy and 50 patients with age and sex matched without the case disease. To all the patients mean platelet volume was done and comparing the significant difference of mean platelet volume between diabetics with retinopathy (cases) and control groups.

Results: The mean platelet volume of the diabetic retinopathy and controls were 11.77 + 1.40 and 7.55 + 0.35. Regarding fasting glucose level for diabetic retinopathy and controls were 196.04 + 13.2 and 103.57+12.16 which is significantly higher than the controls (p value <0.005). Likewise the post prandial values for diabetic retinopathy 329.64 + 47.65, which is significantly higher than the control 160.9 +14.99. (p value <0.005). The HbA1c values for the diabetic retinopathy seems to be 9.78+ 1.01 which is significantly higher than the control groups 5.48+0.94. (p value <0.005).

Conclusion: Mean platelet volume was reported to be raised in diabetic retinopathy patients compared to the healthy population.

Keywords: Diabetic Retinopathy, Mean Platelet Volume, HbA1c, Diabetes Mellitus.


Full Text:

PDF

References


Ji S, Zhang J, Fan X. The relationship between mean platelet volume and diabetic retinopathy. Diabetol Metab Syndr. 2019;11:25.

Sertbas Y, Sertbas M, Okuroglu N, Ozturk MA, Abacar KY, Ozdemir A. Mean platelet volume changes before and after glycated hemoglobin (HbA1c) improvement in a large study population. Arch Med Sci. 2017;13(4):711-5.

Turgutalp K, Ozhan O, Akbay E, Tombak A, Tiftik N, Ozcan T, et al. Mean platelet volume and related factors in patients at different stages of diabetic nephropathy: a preliminary study. Appl Thromb Hemost. 2014;20:190-5.

American Diabetes Association. Standards of medical care in diabetes. Diabet Care. 2012;35(Suppl 1):S11-S63.

Cheng H, Huang HS, Park HK, Chun MY and Sung JY. The role of mean platelet volume as a predicting factor of asymptomatic coronary artery disease. Korean J Fam Med. 2010;8:600-6.

Targutalp K, Ozhan O, Akbay E, Tiftik N Yilmaz S, Kiykim A. Mean platelet volume and related factors in patients at different stages of diabetic nephropathy. Nephro Dial Transplant. 2012;27(2):167-77.

Dolasik I, Sener SY, Celebi K, Aydin ZM, Korkmaz U, Canturk Z. The effect of metformin on mean platelet volume in diabetic patients. Platelets. 2012;4.

Dalamaga M, Karmaniols K, Lekka A, Antonakos G, Thrasyvoulides A, Papadavid E, et al. Platelet markers correlate with glycemic indices in diabetic, but not diabeticmyelodysplastic patients with normal platelet count. Dis Marker. 2010;29:55-61.

Demirtunc R, Duman D, Basar M, Bilgim M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabet Complic. 2009;23:89-94.

Shah B, Sha D, Xie D, Mohler ER, Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the national health and nutrition examination survey, 1999–2004. Diabetes Care. 2012;35:1074-8.

Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2009;15:475-8.

Ateş O, Kiki I, Bilen H, Keleş M, Koçer I, Kulaçoğlu DN, et al. Association of mean platelet volume with the degree of retinopathy in patients with diabetes mellitus. Eur J Gen Med. 2009;6:99-102.