Prevalence of dyslipidemia in newly diagnosed patients of type-2 diabetes mellitus at tertiary care centre of West Uttar Pradesh: A single centre study

Yogita Singh, Devinder Kumar Vohra, Mohd. Misbahuzzama Khan, Ganesh Singh

Abstract


Literature from Indian studies showed a threefold rise in the prevalence of diabetes in rural as well as urban areas and India may become the diabetic capital of the world in near future. Patients suffering from type 2 DM have more risk of developing vascular diseases because of changes in lipid profile. Diabetic dyslipidemia is more atherogenic and is characterised by increase in serum levels of total cholesterol (TC), triglycerides (TGs), or both, or decrease in serum levels of high-density lipoprotein cholesterol (HDL-C). Dyslipidemia is a risk factor for cardiovascular diseases and is modifiable. The present study was conducted to determine the prevalence of dyslipidemia in newly-diagnosed patients of type-2 diabetes mellitus. In the study, 100 newly diagnosed type 2 diabetes patients were included as cases and 100 non-diabetic subjects were included as controls. Blood samples were collected from the subjects of both the study and control groups and were analyzed for fasting and post-prandial plasma glucose, HbA1c, TC, TG, LDL-C, and HDL-C. 84% of cases had dyslipidemia whereas only 52% of controls were found to have dyslipidemia and the difference between the two groups was statistically significant (p<0.05). The mean values of fasting and post-prandial plasma glucose, HbA1c, TC, TG and LDL-C were found to be higher in the cases as compared to the controls (p<0.05). Positive correlation was found between glycemic parameters and Serum – total cholesterol, triglycerides and LDL cholesterol (p<0.05). This study demonstrated that the dyslipidemia is prevalent in newly diagnosed T2DM patients. Hence this study stresses the need and importance of implementation of measures to control dyslipidemia in diabetic patients as dyslipidemia is a known risk factor for cardiovascular diseases.

Keywords: Type 2 diabetes mellitus, HbA1c (Glycosylated haemoglobin), Fasting blood glucose, Dyslipidemia, Triglycerides, High density lipoprotein-cholesterol.


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