Adult granulosa cell tumour with yolk sac like areas in a young female

Yash Kale, Girish Kadkol, Madhura Phadke, Jaydeep Pol

Abstract


Granulosa cell tumour (GST) belongs to the sex-cord/stromal tumours of the gonads. We received slides and blocks for review of a 27 years female whounderwent Right oopherectomy. On microscopic examination, architectural pattern was suggestive of either yolk sac tumor andgranulosa cell tumor. Cellular features were suggestive of Granulosa cell tumor because of presence of nuclear grooves. So we decided to go ahead with immunohistochemistry. We used following IHC markers: Inhibin, Calretinin, EMA (Epithelial Membrane antigen), Glypican and PLAP (Placental alkaline phosphatase). Tumor cells were positive for Inhibin, Calretinin and negative for EMA, Glypican and PLAP. We gave a final diagnosis of adult granulosa cell tumor considering morphological and immunohistochemical findings.

 

Keywords: Sex cord stromal tumor, Granulosa cell tumor, Adult granulosa cell tumor, Inhibin, Calretinin

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References


Scully RE, Young RE, Clement PB (1998) Tumors of the ovary, mal developed gonads, fallopian tube, and broad ligament. In: Atlas of tumor pathology, 3rd series, fasc 23. Armed Forces Institute of Pathology, Washington, DC.

Bjorkholm E, Pettersson F (1980) Granulosa-cell and theca-cell tumors. The clinical picture and long term outcome for the Radium hemmetseries. Acta Obstet Gynecol Scand 59:361–365.

Stenwig JT, Hazekamp JT, Beecham JB. Granulosa cell tumors long-term follow-up. Gynecol Oncol 1979;7:136-52.

Evans AT, Gaffey TA, Malkasian GD, Annegers JF. Clinicopathological review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol 1980;55:231-8.

Malstrom H, Hogberg T, Risberg B, Simonsen E. Granulosa cell tumors of the ovary: Prognostic factors and outcome. Gynecol Oncol 1994;52:50-5.

Stenwig JT, Hazekamp JT, Beecham JB: Granulosa cell tumors of the ovary: clinicopathological study of 118 cases with long-term follow-up. Gynecol Oncol 1979,7:136–152.

N. Colombo1,5, M. Peiretti1, A. Garbi1, S. Carinelli2,4, C. Marini5 & C. Sessa3,4, on behalf of the ESMO Guidelines Working Group* Annals of Oncology 23 (Supplement 7): vii20–vii26, 2012.

Hanna G. Kaspar, MD; Christopher P. Crum, Differential Diagnosis of Gynecologic Disorders— Arch Pathol Lab Med. 2015;139:39–54;

Pectasides D, Pectasides E, Kassanos D. Germ cell tumors of the ovary. Cancer Treat Rev. 2008;34(5):427–441.

Lifschitz-Mercer B, Walt H, Kushnir I, et al. Differentiation potential of ovarian dysgerminoma: an immunohistochemical study of 15 cases. Hum Pathol.1995;26(1):62–66.

Pantanowitz L, Otis CN. Glypican-3 immunohistochemistry in the ovary. Histopathology. 08;53(1):115–117.

Zynger DL, McCallum JC, Luan C, et al. Glypican-3 has a higher sensitivity than alpha-fetoprotein for testicular and ovarian yolk sac tumour: immunohistochemical investigation with analysis of histological growth patterns. Histopathology. 2010;56(6):750–757.